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Combination of low concentrations of bone morphogenic protein (BMP), high concentrations of Nodal/Activin A, and Wnt/-catenin signaling generates definitive endoderm (DE) (Pour et al., 2022)

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This review discusses recent clinical and laboratory studies investigating the neuroprotective properties of metformin against DM-induced neurodegeneration and the roles of various molecular pathways, including mitochondrial dysfunction, oxidative stress, inflammation, apoptosis, and its related cascades